Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

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2,641 – 2,655 of 4,473 results

2,641

Medchemexpress LLC Deferoxamine (mesylate) (Standard) | 138-14-7 | 99.8% | 25 MG

Deferoxamine mesylate (Deferoxamine B mesylate) is an iron chelator that binds to Fe(III) and many other metal cations. It is widely used to reduce iron accumulation and deposition in tissues. It upregulates HIF-1α levels with good antioxidant activity and also shows anti-proliferative activity, inducing apoptosis and autophagy in cancer cells. Deferoxamine mesylate can be used in studies of diabetes, neurodegenerative diseases, as well as anti-cancer and anti-COVID-19 research.

Binds to Fe(III) and many other metal cations.
Reduces iron accumulation and deposition in tissues.
Upregulates HIF-1α levels.
Exhibits good antioxidant activity.
Shows anti-proliferative activity.
Induces apoptosis and autophagy in cancer cells.
Used in studies of diabetes and neurodegenerative diseases.
Used in anti-cancer and anti-COVID-19 research.

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2,642

Medchemexpress LLC Bromocriptine mesylate | 22260-51-1 | 99.9% | 10 MG

Bromocriptine mesylate is a potent dopamine D2/D3 receptor agonist that binds to the D2 dopamine receptor with a pKi of 8.05. It is permeable to the blood-brain barrier.

Potent dopamine D2/D3 receptor agonist
Binds D2 dopamine receptor with pKi of 8.05
Permeable to the blood-brain barrier
Stimulates [35S]-GTPγS binding at D2 dopamine receptor expressed in CHO cells with pEC50 of 8.15±0.05
Strong inhibitor of brain nitric oxide synthase (NOS) (IC50=10±2 μM)
Poorly active towards inducible macrophage NOS (IC50>100 μM)
Potent inhibitor of CYP3A4 with a calculated IC50 value of 1.69 μM
Demonstrates significant anti-immobility action in forced swimming test (FST) and tail suspension test (TST) in mice
Potentiates the anti-immobility action of MPE
Decreases static mechanical allodynia (SMA) score in rats
Induces a significant, dose-dependent decrease in pain scores in the CCI-IoN group

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2,643

Medchemexpress LLC Danofloxacin mesylate | 119478-55-6 | 99.88% | 1 G

Danofloxacin mesylate (CP 76136-27) is a fluoroquinolone veterinary drug with broad-spectrum bactericidal activity. It primarily inhibits the DNA gyrase of bacteria and is a substrate for ATP-dependent efflux transporters (P-gp and MRP2). It is designed for laboratory research.

Fluoroquinolone veterinary drug
Broad-spectrum bactericidal activity
Inhibits bacterial DNA gyrase
Substrate for ATP-dependent efflux transporters (P-gp and MRP2)

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2,644

Medchemexpress LLC Trovafloxacin mesylate | 147059-75-4 | MFCD00913361 | 99.8% | 512.46 g/mol | C21H19F3N4O6S | 25 MG

Trovafloxacin mesylate is a broad-spectrum fluoroquinolone antibiotic and selective pannexin 1 (PANX1) inhibitor supplied as a high-purity solid for research use. It inhibits bacterial DNA gyrase and topoisomerase IV and blocks PANX1 inward currents (IC50 ≈ 4 μM), making it suitable for antibacterial mechanism and ion channel studies.

Broad-spectrum antibacterial activity against Gram-positive, Gram-negative, and anaerobic organisms.
Inhibits DNA gyrase and topoisomerase IV to block bacterial replication.
Selective PANX1 inhibition useful for ion channel and apoptotic fragmentation studies.
High stated purity for consistent experimental results.
Stable solid form with recommended storage under nitrogen at -20°C.

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2,645

Medchemexpress LLC Bromocriptine mesylate | 22260-51-1 | 99.90% | 200 MG

Bromocriptine mesylate is a potent dopamine D2/D3 receptor agonist, binding to the D2 dopamine receptor with a pKi of 8.05. It is permeable to the blood-brain barrier. This compound also acts as a strong inhibitor of brain nitric oxide synthase (NOS) with an IC50 of 10±2 μM for purified neuronal NOS, and poorly inhibits inducible macrophage NOS (IC50>100 μM). Additionally, it is a potent inhibitor of CYP3A4, with a calculated IC50 value of 1.69 μM.

Potent dopamine D2/D3 receptor agonist
Permeable to the blood-brain barrier
Strong inhibitor of brain nitric oxide synthase (NOS)
Potent inhibitor of CYP3A4
Shows anti-immobility action in mice (in FST and TST)
Potentiates the anti-immobility action of MPE
Decreases static mechanical allodynia (SMA) score in rats

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2,646

Medchemexpress LLC Dihydroergotamine mesylate | 6190-39-2 | 99.94% | 50 MG

Dihydroergotamine mesylate is a BBB-permeable ergot alkaloid for the research of migraines. It reduces cell survival in A549 and NCI-H226 cells and inhibits cell survival in Hep3B, PLC/PRF/5, Huh7, and HepG2 cells.

Reduces cell survival in A549 and NCI-H226 cells
Inhibits cell survival in Hep3B, PLC/PRF/5, Huh7, and HepG2 cells
Induces mitochondrial morphologic alterations and dysfunction
Increases ROS generation and induces apoptosis
Disturbs ATP production in A549 cells
Inhibits STAT3 activation and enhances protein stability of Mcl-1

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2,647

eMolecules 7681-84-7 | Tetrahydro-furan-2-carbaldehyde, 50%w/w in toluene | J&W PharmLab LLC | MFCD01726184 | 100.117 | C5H8O2 | 95.000 | O=CC1CCCO1 | 100mg | 592889055

Tetrahydro-furan-2-carbaldehyde, 50%w/w in toluene | J&W PharmLab LLC | 7681-84-7 | MFCD01726184 | 100.117 | C5H8O2 | 95.000 | O=CC1CCCO1 | 100mg | 592889055

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2,648

eMolecules 7681-84-7 | Tetrahydrofuran-2-carbaldehyde, 50% in toluene | Combi-Blocks | MFCD01726184 | 100.117 | C5H8O2 | 90.000 | O=CC1CCCO1 | 250mg | 517119334

Tetrahydrofuran-2-carbaldehyde, 50% in toluene | Combi-Blocks | 7681-84-7 | MFCD01726184 | 100.117 | C5H8O2 | 90.000 | O=CC1CCCO1 | 250mg | 517119334

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2,649

eMolecules 69812-30-2 | 2-ACETAMIDOTHIAZOLE-5-SULFONYL CHLORIDE | AstaTech | MFCD05022486 | 240.680 | C5H5ClN2O3S2 | 95.000 | CC(=O)Nc1ncc(s1)S(Cl)(=O)=O | 0.25g | 233631705

2-ACETAMIDOTHIAZOLE-5-SULFONYL CHLORIDE | AstaTech | 69812-30-2 | MFCD05022486 | 240.680 | C5H5ClN2O3S2 | 95.000 | CC(=O)Nc1ncc(s1)S(Cl)(=O)=O | 0.25g | 233631705

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2,650

eMolecules 88950-64-5 | 1-Aminocyclopropane-1-carboxylic acid, N-BOC protected | Apollo Scientific | MFCD00083257 | 201.222 | C9H15NO4 | 97.000 | CC(C)(C)OC(=O)NC1(CC1)C(O)=O | 1g | 600855395

1-Aminocyclopropane-1-carboxylic acid, N-BOC protected | Apollo Scientific | 88950-64-5 | MFCD00083257 | 201.222 | C9H15NO4 | 97.000 | CC(C)(C)OC(=O)NC1(CC1)C(O)=O | 1g | 600855395

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2,651

eMolecules 287193-07-1 | Ethyl 4-oxooxane-2-carboxylate | ChemScene | MFCD20922879 | 172.180 | C8H12O4 | 95.000 | CCOC(=O)C1CC(=O)CCO1 | 250mg | 572179446

Ethyl 4-oxooxane-2-carboxylate | ChemScene | 287193-07-1 | MFCD20922879 | 172.180 | C8H12O4 | 95.000 | CCOC(=O)C1CC(=O)CCO1 | 250mg | 572179446

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2,652

eMolecules 288154-18-7 | tert-butyl 4-amino-4-carbamoylpiperidine-1-carboxylate | Synthonix | MFCD04114477 | 243.307 | C11H21N3O3 | 97.000 | CC(C)(C)OC(=O)N1CCC(N)(CC1)C(N)=O | 10g | 808568735

tert-butyl 4-amino-4-carbamoylpiperidine-1-carboxylate | Synthonix | 288154-18-7 | MFCD04114477 | 243.307 | C11H21N3O3 | 97.000 | CC(C)(C)OC(=O)N1CCC(N)(CC1)C(N)=O | 10g | 808568735

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2,653

Medchemexpress LLC (R)-Baclofen (Arbaclofen) | 69308-37-8 | 99.50% | 213.66 | 200 MG

R-Baclofen (Arbaclofen) is a selective GABAB receptor agonist commonly used in research. It exhibits agonist activity at human GABA-B B1/B2 receptors expressed in HEK293 cells, as assessed by the inhibition of forskolin-stimulated cAMP accumulation. In vivo studies demonstrate its ability to suppress audiogenic seizures in Fmr1-knockout mice and significantly reduce seizure incidence with acute administration.

Selective GABAB receptor agonist.
Exhibits agonist activity at human GABA-B B1/B2 receptors.
Suppresses audiogenic seizures in Fmr1-knockout mice.
Reduces seizure incidence in mice.

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2,654

Apexbio Technology LLC GSK1070916 942918-07-2 200mg

GSK1070916 (CAS 942918-07-2) is a selective ATP-competitive inhibitor targeting Aurora kinase B and C displaying Ki values of 0 38 nM and 1 5 nM respectively The compound demonstrates marked selectivity over Aurora kinase A with IC50 values of approximately 5 nM (Aurora B) versus 1259 nM (Aurora A) In vitro studies show that GSK1070916 inhibits proliferation of human lung cancer cells (A549) with an EC50 of roughly 7 nM Additionally the compound effectively reduces phosphorylation of histone H3 an Aurora B substrate and exhibits tumor growth inhibition in HL-60 xenograft mouse models GSK1070916 is utilized in tumor biology research investigating Aurora kinase signaling pathways

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2,655

Medchemexpress LLC Acotiamide monohydrochloride trihydrate | 773092-05-0 | 99.8% | 1 G

Acotiamide monohydrochloride trihydrate is an orally active, selective, and reversible acetylcholinesterase (AChE) inhibitor with an IC50 of 1.79 μM. It can enhance gastric contractility and accelerate delayed gastric emptying. It has potential for research into functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory conditions.

Orally active, selective, and reversible acetylcholinesterase (AChE) inhibitor
Enhances gastric contractility and accelerates delayed gastric emptying
Potential for research of functional dyspepsia and intestinal inflammatory conditions

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Quinolines and derivatives

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Medchemexpress LLC Deferoxamine (mesylate) (Standard) | 138-14-7 | 99.8% | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Bromocriptine mesylate | 22260-51-1 | 99.9% | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Danofloxacin mesylate | 119478-55-6 | 99.88% | 1 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Trovafloxacin mesylate | 147059-75-4 | MFCD00913361 | 99.8% | 512.46 g/mol | C21H19F3N4O6S | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Bromocriptine mesylate | 22260-51-1 | 99.90% | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Dihydroergotamine mesylate | 6190-39-2 | 99.94% | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (R)-Baclofen (Arbaclofen) | 69308-37-8 | 99.50% | 213.66 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC GSK1070916 942918-07-2 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Acotiamide monohydrochloride trihydrate | 773092-05-0 | 99.8% | 1 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More